Human CHMP2B activation kit by CRISPRa

CAT#: GA108671

CHMP2B CRISPRa kit - CRISPR gene activation of human charged multivesicular body protein 2B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHMP2B
• Locus ID: 25978
• Kit Components:

  GA108671G1, CHMP2B gRNA vector 1 in pCas-Guide-CRISPRa

  GA108671G2, CHMP2B gRNA vector 2 in pCas-Guide-CRISPRa

  GA108671G3, CHMP2B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001244644, NM_014043
• Synonyms: ALS17; CHMP2.5; DMT1; VPS2-2; VPS2B
• Summary: This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]