Human UPF2 activation kit by CRISPRa

CAT#: GA108699

UPF2 CRISPRa kit - CRISPR gene activation of human UPF2 regulator of nonsense mediated mRNA decay

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: UPF2
• Locus ID: 26019
• Kit Components:

  GA108699G1, UPF2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108699G2, UPF2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108699G3, UPF2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015542, NM_080599
• Synonyms: HUPF2; RENT2; smg-3
• Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]