Human APPL (APPL1) activation kit by CRISPRa

CAT#: GA108731

APPL1 CRISPRa kit - CRISPR gene activation of human adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: APPL1
• Locus ID: 26060
• Kit Components:

  GA108731G1, APPL1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108731G2, APPL1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108731G3, APPL1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_012096
• Synonyms: APPL; DIP13alpha; MODY14
• Summary: The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]