Human RGS17 activation kit by CRISPRa

CAT#: GA108904

RGS17 CRISPRa kit - CRISPR gene activation of human regulator of G protein signaling 17

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RGS17
• Locus ID: 26575
• Kit Components:

  GA108904G1, RGS17 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108904G2, RGS17 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108904G3, RGS17 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_012419
• Synonyms: hRGS17; RGS-17; RGSZ2
• Summary: This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]