Human AP3M1 activation kit by CRISPRa

CAT#: GA108953

AP3M1 CRISPRa kit - CRISPR gene activation of human adaptor related protein complex 3 subunit mu 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AP3M1
• Locus ID: 26985
• Kit Components:

  GA108953G1, AP3M1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108953G2, AP3M1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108953G3, AP3M1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001320263, NM_001320264, NM_001320265, NM_012095, NM_207012, NR_135191
• Summary: The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane, and it may directly function in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2016]