Human PABP (PABPC1) activation kit by CRISPRa

CAT#: GA108954

PABPC1 CRISPRa kit - CRISPR gene activation of human poly(A) binding protein cytoplasmic 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PABPC1
• Locus ID: 26986
• Kit Components:

  GA108954G1, PABPC1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108954G2, PABPC1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108954G3, PABPC1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002568
• Synonyms: PAB1; PABP; PABP1; PABPC2; PABPL1
• Summary: This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes. [provided by RefSeq, Aug 2010]