Human DNAJC2 activation kit by CRISPRa

CAT#: GA108961

DNAJC2 CRISPRa kit - CRISPR gene activation of human DnaJ heat shock protein family (Hsp40) member C2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DNAJC2
• Locus ID: 27000
• Kit Components:

  GA108961G1, DNAJC2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108961G2, DNAJC2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108961G3, DNAJC2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001129887, NM_014377, NM_001362668, NM_001362667
• Synonyms: MPHOSPH11; MPP11; ZRF1; ZUO1
• Summary: This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]