Human Dynein intermediate chain 1 (DNAI1) activation kit by CRISPRa

CAT#: GA108968

DNAI1 CRISPRa kit - CRISPR gene activation of human dynein axonemal intermediate chain 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DNAI1
• Locus ID: 27019
• Kit Components:

  GA108968G1, DNAI1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108968G2, DNAI1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108968G3, DNAI1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001281428, NM_012144
• Synonyms: CILD1; DIC1; ICS1; PCD
• Summary: This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]