Human Bcl2 Binding component 3 (BBC3) activation kit by CRISPRa

CAT#: GA109015

BBC3 CRISPRa kit - CRISPR gene activation of human BCL2 binding component 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BBC3
• Locus ID: 27113
• Kit Components:

  GA109015G1, BBC3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109015G2, BBC3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109015G3, BBC3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001127240, NM_001127241, NM_001127242, NM_014417
• Synonyms: JFY-1; JFY1; PUMA
• Summary: This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]