Human DKK3 activation kit by CRISPRa

CAT#: GA109019

DKK3 CRISPRa kit - CRISPR gene activation of human dickkopf WNT signaling pathway inhibitor 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DKK3
• Locus ID: 27122
• Kit Components:

  GA109019G1, DKK3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109019G2, DKK3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109019G3, DKK3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001018057, NM_001330220, NM_013253, NM_015881
• Synonyms: REIC; RIG
• Summary: This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]