Human DKK2 activation kit by CRISPRa

CAT#: GA109020

DKK2 CRISPRa kit - CRISPR gene activation of human dickkopf WNT signaling pathway inhibitor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DKK2
• Locus ID: 27123
• Kit Components:

  GA109020G1, DKK2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109020G2, DKK2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109020G3, DKK2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014421
• Synonyms: DKK-2
• Summary: This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]