Human DISC1 activation kit by CRISPRa

CAT#: GA109058

DISC1 CRISPRa kit - CRISPR gene activation of human DISC1 scaffold protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DISC1
• Locus ID: 27185
• Kit Components:

  GA109058G1, DISC1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109058G2, DISC1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109058G3, DISC1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001012957, NM_001012958, NM_001012959, NM_001164537, NM_001164538, NM_001164539, NM_001164540, NM_001164541, NM_001164542, NM_001164544, NM_001164545, NM_001164546, NM_001164547, NM_001164548, NM_001164549, NM_001164550, NM_001164551, NM_001164552, NM_001164553, NM_001164554, NM_001164555, NM_001164556, NM_018662
• Synonyms: C1orf136; SCZD9
• Summary: This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]