Human GNMT activation kit by CRISPRa

CAT#: GA109069

GNMT CRISPRa kit - CRISPR gene activation of human glycine N-methyltransferase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GNMT
• Locus ID: 27232
• Kit Components:

  GA109069G1, GNMT gRNA vector 1 in pCas-Guide-CRISPRa

  GA109069G2, GNMT gRNA vector 2 in pCas-Guide-CRISPRa

  GA109069G3, GNMT gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001318865, NM_018960, NR_134899
• Synonyms: glycine N-methyltransferase; OTTHUMP00000016412
• Summary: The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. This protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). Alternative splicing results in multiple transcript variants. Naturally occurring readthrough transcription occurs between the upstream CNPY3 (canopy FGF signaling regulator 3) gene and this gene and is represented with GeneID:107080644. [provided by RefSeq, Jan 2016]