Human CHMP2A activation kit by CRISPRa

CAT#: GA109079

CHMP2A CRISPRa kit - CRISPR gene activation of human charged multivesicular body protein 2A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHMP2A
• Locus ID: 27243
• Kit Components:

  GA109079G1, CHMP2A gRNA vector 1 in pCas-Guide-CRISPRa

  GA109079G2, CHMP2A gRNA vector 2 in pCas-Guide-CRISPRa

  GA109079G3, CHMP2A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014453, NM_198426
• Synonyms: BC-2; BC2; CHMP2; VPS2; VPS2A
• Summary: CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]). [supplied by OMIM, Mar 2008]