Human LSM1 activation kit by CRISPRa

CAT#: GA109091

LSM1 CRISPRa kit - CRISPR gene activation of human LSM1 homolog, mRNA degradation associated

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LSM1
• Locus ID: 27257
• Kit Components:

  GA109091G1, LSM1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109091G2, LSM1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109091G3, LSM1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014462, NR_045492, NR_045493
• Synonyms: CASM; YJL124C
• Summary: This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]