Human ALP (PDLIM3) activation kit by CRISPRa

CAT#: GA109105

PDLIM3 CRISPRa kit - CRISPR gene activation of human PDZ and LIM domain 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDLIM3
• Locus ID: 27295
• Kit Components:

  GA109105G1, PDLIM3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109105G2, PDLIM3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109105G3, PDLIM3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001114107, NM_001257962, NM_001257963, NM_014476, NR_047562
• Synonyms: ALP
• Summary: The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012]