Human SLCO1B3 activation kit by CRISPRa

CAT#: GA109157

SLCO1B3 CRISPRa kit - CRISPR gene activation of human solute carrier organic anion transporter family member 1B3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SLCO1B3
• Locus ID: 28234
• Kit Components:

  GA109157G1, SLCO1B3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109157G2, SLCO1B3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109157G3, SLCO1B3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_019844, NM_001349920
• Synonyms: HBLRR; LST-2; LST-3TM13; LST3; OATP-8; OATP1B3; OATP8; SLC21A8
• Summary: This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. Alternative splicing of this gene and the use of alternative promoters results in transcript variants encoding different isoforms that differ in their tissue specificity. [provided by RefSeq, Mar 2017]