Human robld3 (LAMTOR2) activation kit by CRISPRa

CAT#: GA109167

LAMTOR2 CRISPRa kit - CRISPR gene activation of human late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LAMTOR2
• Locus ID: 28956
• Kit Components:

  GA109167G1, LAMTOR2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109167G2, LAMTOR2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109167G3, LAMTOR2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145264, NM_014017
• Synonyms: ENDAP; HSPC003; MAPBPIP; MAPKSP1AP; p14; Ragulator2; ROBLD3
• Summary: The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]