Human CARD10 activation kit by CRISPRa

CAT#: GA109265

CARD10 CRISPRa kit - CRISPR gene activation of human caspase recruitment domain family member 10

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CARD10
• Locus ID: 29775
• Kit Components:

  GA109265G1, CARD10 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109265G2, CARD10 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109265G3, CARD10 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014550
• Synonyms: BIMP1; CARMA3
• Summary: The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]). [supplied by OMIM, Mar 2008]