Human PSMC3IP activation kit by CRISPRa

CAT#: GA109294

PSMC3IP CRISPRa kit - CRISPR gene activation of human PSMC3 interacting protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PSMC3IP
• Locus ID: 29893
• Kit Components:

  GA109294G1, PSMC3IP gRNA vector 1 in pCas-Guide-CRISPRa

  GA109294G2, PSMC3IP gRNA vector 2 in pCas-Guide-CRISPRa

  GA109294G3, PSMC3IP gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256014, NM_001256015, NM_001256016, NM_013290, NM_016556, NR_045669, NR_045670, NR_045671
• Synonyms: GT198; HOP2; HUMGT198A; ODG3; TBPIP
• Summary: This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2011]