Human PNMA3 activation kit by CRISPRa

CAT#: GA109329

PNMA3 CRISPRa kit - CRISPR gene activation of human PNMA family member 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PNMA3
• Locus ID: 29944
• Kit Components:

  GA109329G1, PNMA3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109329G2, PNMA3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109329G3, PNMA3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001282535, NM_013364
• Synonyms: MA3; MA5
• Summary: The protein encoded by this gene belongs to the paraneoplastic antigen MA (PNMA) family, which shares homology with retroviral Gag proteins. The PNMA antigens are highly expressed in the brain and also in a range of tumors associated with serious neurological phenotypes. PMID:16407312 reports the presence of a functional -1 ribosomal frameshift signal (consisting of a heptanucleotide shift motif followed 3' by a pseudoknot structure) in this gene, however, the frame-shifted product has not been characterized. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]