Human OSGIN1 activation kit by CRISPRa

CAT#: GA109333

OSGIN1 CRISPRa kit - CRISPR gene activation of human oxidative stress induced growth inhibitor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OSGIN1
• Locus ID: 29948
• Kit Components:

  GA109333G1, OSGIN1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109333G2, OSGIN1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109333G3, OSGIN1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_013370, NM_182980, NM_182981
• Synonyms: BDGI; OKL38
• Summary: This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]