Human IL19 activation kit by CRISPRa

CAT#: GA109334

IL19 CRISPRa kit - CRISPR gene activation of human interleukin 19

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL19
• Locus ID: 29949
• Kit Components:

  GA109334G1, IL19 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109334G2, IL19 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109334G3, IL19 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_013371, NM_153758, NM_001369605
• Synonyms: IL-10C; MDA1; NG.1; ZMDA1
• Summary: The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]