Human Kallikrein 14 (KLK14) activation kit by CRISPRa

CAT#: GA109406

KLK14 CRISPRa kit - CRISPR gene activation of human kallikrein related peptidase 14

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KLK14
• Locus ID: 43847
• Kit Components:

  GA109406G1, KLK14 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109406G2, KLK14 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109406G3, KLK14 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001311182, NM_022046, NR_163144, NM_001369775
• Synonyms: KLK-L6
• Summary: This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]