Human p53R2 (RRM2B) activation kit by CRISPRa

CAT#: GA109413

RRM2B CRISPRa kit - CRISPR gene activation of human ribonucleotide reductase regulatory TP53 inducible subunit M2B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RRM2B
• Locus ID: 50484
• Kit Components:

  GA109413G1, RRM2B gRNA vector 1 in pCas-Guide-CRISPRa

  GA109413G2, RRM2B gRNA vector 2 in pCas-Guide-CRISPRa

  GA109413G3, RRM2B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001172477, NM_001172478, NM_015713
• Synonyms: MTDPS8A; MTDPS8B; P53R2
• Summary: This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]