Human CHST11 activation kit by CRISPRa

CAT#: GA109425

CHST11 CRISPRa kit - CRISPR gene activation of human carbohydrate sulfotransferase 11

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHST11
• Locus ID: 50515
• Kit Components:

  GA109425G1, CHST11 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109425G2, CHST11 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109425G3, CHST11 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001173982, NM_018413
• Synonyms: C4ST; C4ST-1; C4ST1; HSA269537
• Summary: The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]