Human KCNK4 activation kit by CRISPRa

CAT#: GA109446

KCNK4 CRISPRa kit - CRISPR gene activation of human potassium two pore domain channel subfamily K member 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNK4
• Locus ID: 50801
• Kit Components:

  GA109446G1, KCNK4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109446G2, KCNK4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109446G3, KCNK4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001317090, NM_016611, NM_033310, NM_033311, NR_133660, NR_133661
• Synonyms: K2p4.1; K2P4.1 potassium channel; potassium channel, subfamily K, member 4; TRAAK; TRAAK, DKFZP566E164; TRAAK1; TWIK-related arachidonic acid-stimulated potassium channel protein; two pore K+ channel KT4.1
• Summary: This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]