Human Junctional Adhesion Molecule 1 (F11R) activation kit by CRISPRa

CAT#: GA109467

F11R CRISPRa kit - CRISPR gene activation of human F11 receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: F11R
• Locus ID: 50848
• Kit Components:

  GA109467G1, F11R gRNA vector 1 in pCas-Guide-CRISPRa

  GA109467G2, F11R gRNA vector 2 in pCas-Guide-CRISPRa

  GA109467G3, F11R gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_016946, NM_144501, NM_144502, NM_144503, NM_144504, NM_001348091
• Synonyms: CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1
• Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]