Human PDE11A activation kit by CRISPRa

CAT#: GA109479

PDE11A CRISPRa kit - CRISPR gene activation of human phosphodiesterase 11A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDE11A
• Locus ID: 50940
• Kit Components:

  GA109479G1, PDE11A gRNA vector 1 in pCas-Guide-CRISPRa

  GA109479G2, PDE11A gRNA vector 2 in pCas-Guide-CRISPRa

  GA109479G3, PDE11A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001077196, NM_001077197, NM_001077358, NM_016953
• Synonyms: PPNAD2
• Summary: The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]