Human Sclerostin (SOST) activation kit by CRISPRa

CAT#: GA109483

SOST CRISPRa kit - CRISPR gene activation of human sclerostin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SOST
• Locus ID: 50964
• Kit Components:

  GA109483G1, SOST gRNA vector 1 in pCas-Guide-CRISPRa

  GA109483G2, SOST gRNA vector 2 in pCas-Guide-CRISPRa

  GA109483G3, SOST gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_025237
• Synonyms: CDD; DAND6; SOST1; VBCH
• Summary: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]