Human ThPok (ZBTB7B) activation kit by CRISPRa

CAT#: GA109518

ZBTB7B CRISPRa kit - CRISPR gene activation of human zinc finger and BTB domain containing 7B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ZBTB7B
• Locus ID: 51043
• Kit Components:

  GA109518G1, ZBTB7B gRNA vector 1 in pCas-Guide-CRISPRa

  GA109518G2, ZBTB7B gRNA vector 2 in pCas-Guide-CRISPRa

  GA109518G3, ZBTB7B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001252406, NM_001256455, NM_015872, NR_045515, NR_046206, NR_049765
• Synonyms: c-KROX; CKROX; hcKROX; THPOK; ZBTB15; ZFP-67; ZFP67; ZNF857B
• Summary: This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]