Human Geminin (GMNN) activation kit by CRISPRa

CAT#: GA109522

GMNN CRISPRa kit - CRISPR gene activation of human geminin DNA replication inhibitor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GMNN
• Locus ID: 51053
• Kit Components:

  GA109522G1, GMNN gRNA vector 1 in pCas-Guide-CRISPRa

  GA109522G2, GMNN gRNA vector 2 in pCas-Guide-CRISPRa

  GA109522G3, GMNN gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001251989, NM_001251990, NM_001251991, NM_015895
• Synonyms: Gem; MGORS6
• Summary: This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]