Human Shwachman Bodian Diamond syndrome (SBDS) activation kit by CRISPRa

CAT#: GA109582

SBDS CRISPRa kit - CRISPR gene activation of human SBDS ribosome maturation factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SBDS
• Locus ID: 51119
• Kit Components:

  GA109582G1, SBDS gRNA vector 1 in pCas-Guide-CRISPRa

  GA109582G2, SBDS gRNA vector 2 in pCas-Guide-CRISPRa

  GA109582G3, SBDS gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_016038
• Synonyms: CGI-97; SDS; SWDS
• Summary: This gene encodes a highly conserved protein that plays an essential role in ribosome biogenesis. The encoded protein interacts with elongation factor-like GTPase 1 to disassociate eukaryotic initiation factor 6 from the late cytoplasmic pre-60S ribosomal subunit allowing assembly of the 80S subunit. Mutations within this gene are associated with the autosomal recessive disorder Shwachman-Bodian-Diamond syndrome. This gene has a closely linked pseudogene that is distally located. [provided by RefSeq, Jan 2017]