Human LEF1 activation kit by CRISPRa

CAT#: GA109627

LEF1 CRISPRa kit - CRISPR gene activation of human lymphoid enhancer binding factor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LEF1
• Locus ID: 51176
• Kit Components:

  GA109627G1, LEF1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109627G2, LEF1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109627G3, LEF1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001130713, NM_001130714, NM_001166119, NM_016269
• Synonyms: LEF-1; TCF1ALPHA; TCF7L3; TCF10
• Summary: This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]