Human PIGP activation kit by CRISPRa

CAT#: GA109660

PIGP CRISPRa kit - CRISPR gene activation of human phosphatidylinositol glycan anchor biosynthesis class P

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PIGP
• Locus ID: 51227
• Kit Components:

  GA109660G1, PIGP gRNA vector 1 in pCas-Guide-CRISPRa

  GA109660G2, PIGP gRNA vector 2 in pCas-Guide-CRISPRa

  GA109660G3, PIGP gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_016430, NM_153681, NM_153682, NR_028352, NM_001320480
• Synonyms: DCRC; DCRC-S; DSRC; PIG-P; PIGP
• Summary: This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. This gene has multiple pseudogenes and is a member of the phosphatidylinositol glycan anchor biosynthesis gene family. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]