Human Neuritin (NRN1) activation kit by CRISPRa

CAT#: GA109718

NRN1 CRISPRa kit - CRISPR gene activation of human neuritin 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NRN1
• Locus ID: 51299
• Kit Components:

  GA109718G1, NRN1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109718G2, NRN1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109718G3, NRN1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001278710, NM_001278711, NM_016588
• Synonyms: dJ380B8.2; NRN
• Summary: This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]