Human EDD (UBR5) activation kit by CRISPRa

CAT#: GA109767

UBR5 CRISPRa kit - CRISPR gene activation of human ubiquitin protein ligase E3 component n-recognin 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: UBR5
• Locus ID: 51366
• Kit Components:

  GA109767G1, UBR5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109767G2, UBR5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109767G3, UBR5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001282873, NM_015902
• Synonyms: DD5; EDD; EDD1; HYD
• Summary: This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]