Human HSPC014 (POMP) activation kit by CRISPRa

CAT#: GA109770

POMP CRISPRa kit - CRISPR gene activation of human proteasome maturation protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: POMP
• Locus ID: 51371
• Kit Components:

  GA109770G1, POMP gRNA vector 1 in pCas-Guide-CRISPRa

  GA109770G2, POMP gRNA vector 2 in pCas-Guide-CRISPRa

  GA109770G3, POMP gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015932
• Synonyms: C13orf12; HSPC014; PNAS-110; UMP1
• Summary: The protein encoded by this gene is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome complex. The encoded protein is degraded before the maturation of the 20S proteasome is complete. A variant in the 5' UTR of this gene has been associated with KLICK syndrome, a rare skin disorder. [provided by RefSeq, Aug 2010]