Human PRKAG2 activation kit by CRISPRa

CAT#: GA109796

PRKAG2 CRISPRa kit - CRISPR gene activation of human protein kinase AMP-activated non-catalytic subunit gamma 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PRKAG2
• Locus ID: 51422
• Kit Components:

  GA109796G1, PRKAG2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109796G2, PRKAG2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109796G3, PRKAG2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001040633, NM_001304527, NM_001304531, NM_016203, NM_024429, NM_001363698
• Synonyms: AAKG; AAKG2; CMH6; H91620p; WPWS
• Summary: AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family. Mutations in this gene have been associated with Wolff-Parkinson-White syndrome, familial hypertrophic cardiomyopathy, and glycogen storage disease of the heart. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2015]