Human Leucyl tRNA synthetase (LARS) activation kit by CRISPRa

CAT#: GA109848

LARS CRISPRa kit - CRISPR gene activation of human leucyl-tRNA synthetase


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USD 1,290.00

2 Weeks*

Size
    • 1 kit

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Specifications

Product Data
Format 3gRNAs, 1 scramble ctrl and 1 enhancer vector
Symbol LARS
Locus ID 51520
Kit Components

GA109848G1, LARS gRNA vector 1 in pCas-Guide-CRISPRa

GA109848G2, LARS gRNA vector 2 in pCas-Guide-CRISPRa

GA109848G3, LARS gRNA vector 3 in pCas-Guide-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100058

Disclaimer The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001317964, NM_001317965, NM_016460, NM_020117
Synonyms hr025Cl; HSPC192; ILFS1; LARS1; LEURS; LEUS; LFIS; LRS; PIG44; RNTLS
Summary This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015]

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.