Human Apc11 (ANAPC11) activation kit by CRISPRa

CAT#: GA109855

ANAPC11 CRISPRa kit - CRISPR gene activation of human anaphase promoting complex subunit 11

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ANAPC11
• Locus ID: 51529
• Kit Components:

  GA109855G1, ANAPC11 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109855G2, ANAPC11 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109855G3, ANAPC11 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001002244, NM_001002245, NM_001002246, NM_001002247, NM_001002248, NM_001002249, NM_001289414, NM_001289415, NM_001289416, NM_001289417, NM_001289418, NM_001289419, NM_001289420, NM_016476
• Synonyms: APC11; Apc11p; HSPC214
• Summary: Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. [UniProtKB/Swiss-Prot Function]