Human SIRT6 activation kit by CRISPRa

CAT#: GA109867

SIRT6 CRISPRa kit - CRISPR gene activation of human sirtuin 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SIRT6
• Locus ID: 51548
• Kit Components:

  GA109867G1, SIRT6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109867G2, SIRT6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109867G3, SIRT6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001193285, NM_001321058, NM_001321059, NM_001321060, NM_001321061, NM_001321062, NM_001321063, NM_001321064, NM_016539
• Synonyms: SIR2L6
• Summary: This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]