Human IL23 (IL23A) activation kit by CRISPRa

CAT#: GA109875

IL23A CRISPRa kit - CRISPR gene activation of human interleukin 23 subunit alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL23A
• Locus ID: 51561
• Kit Components:

  GA109875G1, IL23A gRNA vector 1 in pCas-Guide-CRISPRa

  GA109875G2, IL23A gRNA vector 2 in pCas-Guide-CRISPRa

  GA109875G3, IL23A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_016584
• Synonyms: IL-23; IL-23A; IL23P19; P19; SGRF
• Summary: This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]