Human DC2L1 (DYNC2LI1) activation kit by CRISPRa

CAT#: GA109908

DYNC2LI1 CRISPRa kit - CRISPR gene activation of human dynein cytoplasmic 2 light intermediate chain 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DYNC2LI1
• Locus ID: 51626
• Kit Components:

  GA109908G1, DYNC2LI1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109908G2, DYNC2LI1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109908G3, DYNC2LI1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001012665, NM_001193464, NM_015522, NM_016008, NM_001348912, NM_001348913
• Synonyms: CGI-60; D2LIC; DKFZp564A033; dynein, cytoplasmic 2, light intermediate chain 1; dynein 2 light intermediate chain; LIC3
• Summary: This gene encodes a protein that is a component of the dynein-2 microtubule motor protein complex that plays a role in the retrograde transport of cargo in primary cilia via the intraflagellar transport system. This gene is ubiquitously expressed and its protein, which localizes to the axoneme and Golgi apparatus, interacts directly with the cytoplasmic dynein 2 heavy chain 1 protein to form part of the multi-protein dynein-2 complex. Mutations in this gene produce defects in the dynein-2 complex which result in several types of ciliopathy including short-rib thoracic dysplasia 15 with polydactyly (SRTD15). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]