Human VPS24 (CHMP3) activation kit by CRISPRa

CAT#: GA109924

CHMP3 CRISPRa kit - CRISPR gene activation of human charged multivesicular body protein 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHMP3
• Locus ID: 51652
• Kit Components:

  GA109924G1, CHMP3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109924G2, CHMP3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109924G3, CHMP3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001005753, NM_001193517, NM_016079, NR_036454
• Synonyms: CGI-149; NEDF; VPS24
• Summary: This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010]