Human POLR3K activation kit by CRISPRa

CAT#: GA109963

POLR3K CRISPRa kit - CRISPR gene activation of human RNA polymerase III subunit K

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: POLR3K
• Locus ID: 51728
• Kit Components:

  GA109963G1, POLR3K gRNA vector 1 in pCas-Guide-CRISPRa

  GA109963G2, POLR3K gRNA vector 2 in pCas-Guide-CRISPRa

  GA109963G3, POLR3K gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_016310
• Synonyms: C11; C11-RNP3; My010; RPC10; RPC11; RPC12.5
• Summary: This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17. [provided by RefSeq, Jul 2010]