Human WWOX activation kit by CRISPRa

CAT#: GA109969

WWOX CRISPRa kit - CRISPR gene activation of human WW domain containing oxidoreductase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: WWOX
• Locus ID: 51741
• Kit Components:

  GA109969G1, WWOX gRNA vector 1 in pCas-Guide-CRISPRa

  GA109969G2, WWOX gRNA vector 2 in pCas-Guide-CRISPRa

  GA109969G3, WWOX gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001291997, NM_016373, NM_018560, NM_130788, NM_130790, NM_130791, NM_130792, NM_130844, NR_120435, NR_120436
• Synonyms: D16S432E; FOR; FRA16D; HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1
• Summary: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]