Human BRCAA1 (ARID4B) activation kit by CRISPRa

CAT#: GA109970

ARID4B CRISPRa kit - CRISPR gene activation of human AT-rich interaction domain 4B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARID4B
• Locus ID: 51742
• Kit Components:

  GA109970G1, ARID4B gRNA vector 1 in pCas-Guide-CRISPRa

  GA109970G2, ARID4B gRNA vector 2 in pCas-Guide-CRISPRa

  GA109970G3, ARID4B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001206794, NM_016374, NM_031371, NR_135074
• Synonyms: BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180
• Summary: This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]