Human RTEL1 activation kit by CRISPRa

CAT#: GA109973

RTEL1 CRISPRa kit - CRISPR gene activation of human regulator of telomere elongation helicase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RTEL1
• Locus ID: 51750
• Kit Components:

  GA109973G1, RTEL1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109973G2, RTEL1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109973G3, RTEL1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001283009, NM_001283010, NM_016434, NM_032957
• Synonyms: C20orf41; DKCA4; DKCB5; NHL; RTEL
• Summary: This gene encodes a DNA helicase which functions in the stability, protection and elongation of telomeres and interacts with proteins in the shelterin complex known to protect telomeres during DNA replication. Mutations in this gene have been associated with dyskeratosis congenita and Hoyerall-Hreidarsson syndrome. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, generates a non-coding transcript. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]