Human ARTS1 (ERAP1) activation kit by CRISPRa

CAT#: GA109975

ERAP1 CRISPRa kit - CRISPR gene activation of human endoplasmic reticulum aminopeptidase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ERAP1
• Locus ID: 51752
• Kit Components:

  GA109975G1, ERAP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109975G2, ERAP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109975G3, ERAP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001040458, NM_001198541, NM_016442, NM_001349244
• Synonyms: A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP; ERAAP1; PILS-AP; PILSAP
• Summary: The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]